5-Hydroxytryptamine-2 antagonist increases human slow wave sleep

@article{Idzikowski19865Hydroxytryptamine2AI,
  title={5-Hydroxytryptamine-2 antagonist increases human slow wave sleep},
  author={C. Idzikowski and F. J. Mills and R. Glennard},
  journal={Brain Research},
  year={1986},
  volume={378},
  pages={164-168}
}
Ritanserin, a specific 5-HT2 antagonist, was given to volunteers in a double-blind placebo controlled sleep study. Slow wave sleep doubled in duration at the expense of stage 2. The finding that a serotonin antagonist changed the architecture of sleep without producing insomnia is of fundamental importance and calls for a re-examination of traditional theories of sleep control which assign a facilitatory role to serotonin. 
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