5-Hydroxytryptamine (Serotonin)2A Receptors in Rat Anterior Cingulate Cortex Mediate the Discriminative Stimulus Properties of d-Lysergic Acid Diethylamide

@article{Gresch20075HydroxytryptamineR,
  title={5-Hydroxytryptamine (Serotonin)2A Receptors in Rat Anterior Cingulate Cortex Mediate the Discriminative Stimulus Properties of d-Lysergic Acid Diethylamide},
  author={P. Gresch and R. Barrett and E. sanders-Bush and R. Smith},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  year={2007},
  volume={320},
  pages={662 - 669}
}
d-Lysergic acid diethylamide (LSD), an indoleamine hallucinogen, produces profound alterations in mood, thought, and perception in humans. The brain site(s) that mediates the effects of LSD is currently unknown. In this study, we combine the drug discrimination paradigm with intracerebral microinjections to investigate the anatomical localization of the discriminative stimulus of LSD in rats. Based on our previous findings, we targeted the anterior cingulate cortex (ACC) to test its involvement… Expand
View on ASPET
jpet.aspetjournals.org
29 Citations
Highly Influential Citations
5
Background Citations
17
Methods Citations
2
Results Citations
1

29 Citations

Citation Type

Citation Type

Serotonin type 5A receptor antagonists inhibit D-lysergic acid diethylamide discriminatory cue in rats
  • 3
Re-evaluation of the discriminative stimulus effects of lysergic acid diethylamide with male and female Sprague-Dawley rats
Serotonin (5-hydroxytryptamine) 5-HT2A receptor: association with inherent and cocaine-evoked behavioral disinhibition in rats
  • 36
  • Highly Influenced
Recent advances in the neuropsychopharmacology of serotonergic hallucinogens
  • 135
  • Highly Influenced
  • PDF
Chronic Phenethylamine Hallucinogen Treatment Alters Behavioral Sensitivity to a Metabotropic Glutamate 2/3 Receptor Agonist
  • 18
  • PDF
Head-twitch response in rodents induced by the hallucinogen 2,5-dimethoxy-4-iodoamphetamine: a comprehensive history, a re-evaluation of mechanisms, and its utility as a model.
  • 95
  • Highly Influenced
Multiple receptors contribute to the behavioral effects of indoleamine hallucinogens
  • 154
Blockade of 5-HT2A receptors in the medial prefrontal cortex attenuates reinstatement of cue-elicited cocaine-seeking behavior in rats
  • 56
  • Highly Influenced
  • PDF
Blockade of the serotonin 5-HT2A receptor suppresses cue-evoked reinstatement of cocaine-seeking behavior in a rat self-administration model.
  • 83
Animal models of serotonergic psychedelics.
  • 80
...
1
2
3
...

References

SHOWING 1-10 OF 54 REFERENCES
Lysergic acid diethylamide-induced Fos expression in rat brain: role of serotonin-2A receptors
  • 49
Neuropharmacological reassessment of the discriminative stimulus properties ofd-lysergic acid diethylamide (LSD)
  • 50
  • Highly Influential
The 5-HT1A receptor and the stimulus effects of LSD in the rat
  • 41
Behavioral Tolerance to Lysergic Acid Diethylamide is Associated with Reduced Serotonin-2A Receptor Signaling in Rat Cortex
  • 39
  • PDF
Characterization of the discriminative stimulus properties of centrally administered (−)-DOM and LSD
  • 7
  • Highly Influential
Complex discriminative stimulus properties of (+)lysergic acid diethylamide (LSD) in C57Bl/6J mice
  • 24
Serotonergic/glutamatergic interactions: the effects of mGlu2/3 receptor ligands in rats trained with LSD and PCP as discriminative stimuli
  • 69
Discriminative stimulus properties of lysergic acid diethylamide in the monkey.
  • E. B. Nielsen
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental therapeutics
  • 1985
  • 25
Discriminative stimulus effects of 3,4-methylenedioxymethamphetamine (MDMA) in humans trained to discriminate among d-amphetamine, meta-chlorophenylpiperazine and placebo.
  • 56
The role of the 5-HT2A and 5-HT2C receptors in the stimulus effects of hallucinogenic drugs III: the mechanistic basis for supersensitivity to the LSD stimulus following serotonin depletion
  • 42
...
1
2
3
4
5
...