5-Hydroxytryptamine (Serotonin)2A Receptors in Rat Anterior Cingulate Cortex Mediate the Discriminative Stimulus Properties of d-Lysergic Acid Diethylamide

  title={5-Hydroxytryptamine (Serotonin)2A Receptors in Rat Anterior Cingulate Cortex Mediate the Discriminative Stimulus Properties of d-Lysergic Acid Diethylamide},
  author={P. Gresch and R. Barrett and E. sanders-Bush and R. Smith},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  pages={662 - 669}
d-Lysergic acid diethylamide (LSD), an indoleamine hallucinogen, produces profound alterations in mood, thought, and perception in humans. The brain site(s) that mediates the effects of LSD is currently unknown. In this study, we combine the drug discrimination paradigm with intracerebral microinjections to investigate the anatomical localization of the discriminative stimulus of LSD in rats. Based on our previous findings, we targeted the anterior cingulate cortex (ACC) to test its involvement… Expand
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  • 80


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  • 49
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  • 7
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  • 24
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  • E. B. Nielsen
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental therapeutics
  • 1985
  • 25