5-Hydroxymethyluracil-DNA glycosylase activity may be a differentiated mammalian function.

@article{Boorstein19875HydroxymethyluracilDNAGA,
  title={5-Hydroxymethyluracil-DNA glycosylase activity may be a differentiated mammalian function.},
  author={Robert J. Boorstein and Dan D. Levy and George W. Teebor},
  journal={Mutation research},
  year={1987},
  volume={183 3},
  pages={
          257-63
        }
}
To determine the prevalence of the repair enzyme HMU-DNA glycosylase we assayed its activity in whole cell extracts of several bacterial species, the eukaryotic yeast Saccharomyces cerevisiae, mammalian cell lines and murine tissue. Enzyme activity was constitutively present in murine, hamster and human cell lines. It was not inducible by exposing cells to oxidative stress from ionizing radiation or by incubating cells with the 2'-deoxynucleoside of HMU, HMdU. In murine tissue, enzyme activity… CONTINUE READING