5-Hydroxymethylcytosine is strongly depleted in human cancers but its levels do not correlate with IDH1 mutations.

@article{Jin20115HydroxymethylcytosineIS,
  title={5-Hydroxymethylcytosine is strongly depleted in human cancers but its levels do not correlate with IDH1 mutations.},
  author={Seung-gi Jin and Yong Jiang and Runxiang Qiu and Tibor A. Rauch and Yinsheng Wang and Gabriele Schackert and Dietmar Krex and Qiang Lu and Gerd. P. Pfeifer},
  journal={Cancer research},
  year={2011},
  volume={71 24},
  pages={7360-5}
}
The base 5-hydroxymethylcytosine (5hmC) was recently identified as an oxidation product of 5-methylcytosine in mammalian DNA. Here, using sensitive and quantitative methods to assess levels of 5-hydroxymethyl-2'-deoxycytidine (5hmdC) and 5-methyl-2'-deoxycytidine (5mdC) in genomic DNA, we investigated whether levels of 5hmC can distinguish normal tissue from tumor tissue. In squamous cell lung cancers, levels of 5hmdC were depleted substantially with up to 5-fold reduction compared with normal… CONTINUE READING