5-HTTLPR status predictive of neocortical 5-HT<ce:inf loc=post>4</ce:inf> binding assessed with [<ce:sup loc=pre>11</ce:sup>C]SB207145 PET in humans

@article{Fisher20125HTTLPRSP,
  title={5-HTTLPR status predictive of neocortical 5-HT<ce:inf loc=post>4</ce:inf> binding assessed with [<ce:sup loc=pre>11</ce:sup>C]SB207145 PET in humans},
  author={Patrick MacDonald Fisher and Klaus K. Holst and Brenda McMahon and Mette E. Haahr and Karine Madsen and Nic Gillings and William F. C. Baar{\'e} and Peter S. Jensen and Gitte Moos Knudsen},
  journal={NeuroImage},
  year={2012},
  volume={62},
  pages={130-136}
}
Serotonin (5-HT) is a neuromodulator affecting myriad aspects of personality and behavior and has been implicated in the pathophysiology of affective disorders including depression and anxiety. The 5-HTTLPR is a common genetic polymorphism within the promoter region of the gene coding for the serotonin transporter such that the S allele is associated with reduced transcriptional efficacy compared to the L allele, potentially contributing to increased serotonin levels. In humans, this genetic… CONTINUE READING
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brain: a [(11)C]SB207145 PET study

  • K. Madsen, L. Marner, M. Haahr, N. Gillings, G. M. Knudsen
  • J. Cereb. Blood Flow Metab
  • 2011
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