5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression

  title={5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression},
  author={L. Pezawas and A. Meyer-Lindenberg and E. M. Drabant and B. Verchinski and K. E. Mu{\~n}oz and B. Kolachana and M. Egan and V. Mattay and A. Hariri and D. Weinberger},
  journal={Nature Neuroscience},
  • L. Pezawas, A. Meyer-Lindenberg, +7 authors D. Weinberger
  • Published 2005
  • Psychology, Medicine
  • Nature Neuroscience
  • Carriers of the short allele of a functional 5′ promoter polymorphism of the serotonin transporter gene have increased anxiety-related temperamental traits, increased amygdala reactivity and elevated risk of depression. Here, we used multimodal neuroimaging in a large sample of healthy human subjects to elucidate neural mechanisms underlying this complex genetic association. Morphometrical analyses showed reduced gray matter volume in short-allele carriers in limbic regions critical for… CONTINUE READING
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