5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression

@article{Pezawas20055HTTLPRPI,
  title={5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression},
  author={L. Pezawas and A. Meyer-Lindenberg and E. M. Drabant and B. Verchinski and K. E. Mu{\~n}oz and B. Kolachana and M. Egan and V. Mattay and A. Hariri and D. Weinberger},
  journal={Nature Neuroscience},
  year={2005},
  volume={8},
  pages={828-834}
}
  • L. Pezawas, A. Meyer-Lindenberg, +7 authors D. Weinberger
  • Published 2005
  • Psychology, Medicine
  • Nature Neuroscience
  • Carriers of the short allele of a functional 5′ promoter polymorphism of the serotonin transporter gene have increased anxiety-related temperamental traits, increased amygdala reactivity and elevated risk of depression. Here, we used multimodal neuroimaging in a large sample of healthy human subjects to elucidate neural mechanisms underlying this complex genetic association. Morphometrical analyses showed reduced gray matter volume in short-allele carriers in limbic regions critical for… CONTINUE READING
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    References

    SHOWING 1-10 OF 61 REFERENCES
    A susceptibility gene for affective disorders and the response of the human amygdala.
    • 792
    • PDF
    Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia
    • 2,320
    • PDF
    Amygdala-prefrontal coupling depends on a genetic variation of the serotonin transporter
    • 668
    Meta-analysis of serotonin transporter polymorphisms and affective disorders
    • 257
    Meta‐analysis of the association between a serotonin transporter promoter polymorphism (5‐HTTLPR) and anxiety‐related personality traits
    • S. Sen, M. Burmeister, D. Ghosh
    • Biology, Medicine
    • American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
    • 2004
    • 654
    • PDF
    Serotonin transporter: gene, genetic disorders, and pharmacogenetics.
    • 404
    Gene–environment interaction analysis of serotonin system markers with adolescent depression
    • 644
    • PDF