5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression

@article{Pezawas20055HTTLPRPI,
  title={5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression},
  author={Lukas Pezawas and Andreas Meyer-Lindenberg and Emily M. Drabant and Beth A. Verchinski and Karen E. Mu{\~n}oz and Bhaskar S. Kolachana and Michael Egan and Venkata S. Mattay and Ahmad R. Hariri and Daniel R. Weinberger},
  journal={Nature Neuroscience},
  year={2005},
  volume={8},
  pages={828-834}
}
Carriers of the short allele of a functional 5′ promoter polymorphism of the serotonin transporter gene have increased anxiety-related temperamental traits, increased amygdala reactivity and elevated risk of depression. Here, we used multimodal neuroimaging in a large sample of healthy human subjects to elucidate neural mechanisms underlying this complex genetic association. Morphometrical analyses showed reduced gray matter volume in short-allele carriers in limbic regions critical for… Expand
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