5-HTTLPR genotype and daily negative mood moderate the effects of sertraline on drinking intensity.

@article{Kranzler20135HTTLPRGA,
  title={5-HTTLPR genotype and daily negative mood moderate the effects of sertraline on drinking intensity.},
  author={Henry R. Kranzler and Stephen Armeli and Howard Tennen and Jonathan Covault},
  journal={Addiction biology},
  year={2013},
  volume={18 6},
  pages={1024-31}
}
We previously reported moderating effects of age of onset of alcohol dependence (AD) and a functional polymorphism (5-HTTLPR) in the gene encoding the serotonin transporter protein in a sample of 134 individuals participating in a 12-week, placebo-controlled trial of sertraline. To understand more fully the effects seen in that study, we examined moderation by negative moods reported each evening, with nighttime drinking intensity (i.e. the number of standard drinks consumed at night) as the… CONTINUE READING