5-HT7 receptor-dependent intestinal neurite outgrowth contributes to visceral hypersensitivity in irritable bowel syndrome

@article{Chang20225HT7RI,
  title={5-HT7 receptor-dependent intestinal neurite outgrowth contributes to visceral hypersensitivity in irritable bowel syndrome},
  author={Wen-Ying Chang and Yi-Ting Yang and Meng-Ping She and Chia-Hung Tu and Tsung‐Chun Lee and Ming-Shiang Wu and Chin-Hung Sun and Ling-Wei Hsin and Linda Chia-Hui Yu},
  journal={Laboratory Investigation; a Journal of Technical Methods and Pathology},
  year={2022},
  volume={102},
  pages={1023 - 1037}
}
Irritable bowel syndrome (IBS) is characterized by visceral hypersensitivity (VH) associated with abnormal serotonin/5-hydroxytryptamine (5-HT) metabolism and neurotrophin-dependent mucosal neurite outgrowth. The underlying mechanisms of VH remain poorly understood. We investigated the role of 5-HT7 receptor in mucosal innervation and intestinal hyperalgesia. A high density of mucosal nerve fibres stained for 5-HT7 was observed in colonoscopic biopsy specimens from IBS patients compared with… 

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