5-HT7 receptor activation inhibits mechanical hypersensitivity secondary to capsaicin sensitization in mice

@article{Brenchat20095HT7RA,
  title={5-HT7 receptor activation inhibits mechanical hypersensitivity secondary to capsaicin sensitization in mice},
  author={A. Brenchat and L. Romero and Monica Garcia and M. Pujol and J. Vela},
  journal={PAIN},
  year={2009},
  volume={141},
  pages={239-247}
}
ABSTRACT This work aimed to evaluate the potential role of the 5‐HT7 receptor in nociception secondary to a sensitizing stimulus in mice. For this purpose, the effects of relevant ligands (5‐HT7 receptor agonists: AS‐19, MSD‐5a, E‐55888; 5‐HT7 receptor antagonists: SB‐258719, SB‐269970; 5‐HT1A receptor agonist: F‐13640; 5‐HT1A receptor antagonist: WAY‐100635) were assessed on capsaicin‐induced mechanical hypersensitivity, a pain behavior involving hypersensitivity of dorsal horn neurons… Expand
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