5-HT7 Receptor Inhibition and Inactivation Induce Antidepressantlike Behavior and Sleep Pattern

@article{Hedlund20055HT7RI,
  title={5-HT7 Receptor Inhibition and Inactivation Induce Antidepressantlike Behavior and Sleep Pattern},
  author={Peter B. Hedlund and Salvador Huitr{\'o}n-Res{\'e}ndiz and Steven J. Henriksen and J. Gregor Sutcliffe},
  journal={Biological Psychiatry},
  year={2005},
  volume={58},
  pages={831-837}
}
BACKGROUND The 5-hydroxytryptamine7 receptor (5-HT7) is implicated in circadian rhythm phase resetting, and 5-HT7 receptor-selective antagonists alter rapid eye movement (REM) sleep parameters in a pattern opposite from those in patients with clinical depression. METHODS As sleep, circadian rhythm, and mood regulation are related, we examined 5-HT7 receptor knockout mice in two behavioral models of depression. The forced swim and tail suspension tests are highly predictive for antidepressant… CONTINUE READING
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