5-HT6/7 Receptor Antagonists Facilitate Dopamine Release in the Cochlea via a GABAergic Disinhibitory Mechanism

  title={5-HT6/7 Receptor Antagonists Facilitate Dopamine Release in the Cochlea via a GABAergic Disinhibitory Mechanism},
  author={Zolt{\'a}n Dolevicz{\'e}nyi and E Sylvester Vizi and Istv{\'a}n Gacs{\'a}lyi and Katalin Pallagi and Bal{\'a}zs Volk and L{\'a}szl{\'o} G{\'a}bor H{\'a}rsing and Gy{\"o}rgy Halmos and Bal{\'a}zs Lendvai and Tibor Zelles},
  journal={Neurochemical Research},
In humans, serotonin (5-HT) has been implicated in numerous physiological and pathological processes in the peripheral auditory system. Dopamine (DA), another transmitter of the lateral olivocochlear (LOC) efferents making synapses on cochlear nerve dendrites, controls auditory nerve activation and protects the sensory nerve against overactivation. Using in vitro microvolume superfusion techniques we tested 5-HT6 and 5-HT7 receptor antagonists whether they can influence dopamine (DA) release… 

The central role of 5-HT6 receptors in modulating brain neurochemistry.

  • L. Dawson
  • Biology
    International review of neurobiology
  • 2011

Chemical neuroprotection in the cochlea: The modulation of dopamine release from lateral olivocochlear efferents

Serotonin receptors of type 6 (5-HT6): what can we expect from them?

A comprehensive review on the status of art of the 5-HT6 receptors is reported, while highlighting the potential clinical applications of 5- HT6 receptor agonists/antagonists.

Chronic Oral Selegiline Treatment Mitigates Age-Related Hearing Loss in BALB/c Mice

It is suggested that selegiline can partially preserve the hearing in certain forms of ARHL by alleviating its development and might also be otoprotective in other mammals or humans.

Elucidation of Molecular Mechanism(s) of Cognition Enhancing Activity of Bacomind®: A Standardized Extract of Bacopa Monnieri

BacoMind (BM), a standardized extract of B. monnieri, was found to inhibit three enzymes namely, Catechol-O-methyl transferase (COMT), Prolyl endopeptidase (PEP), and Poly (ADP-ribose) polymerase (PARP) and exhibited an antagonistic effect on5-HT 6 and 5-HT 2A receptors.

Vortioxetine Improved Depressive State In Parkinson’s Disease

The case of a 67-year-old Japanese Parkinson’s disease patient with depression who was successfully treated with vortioxetine, which improved her depressive state without worsening PD.

Pd/Cu-Catalyzed Enantioselective Sequential Heck-Sonogashira Coupling: Asymmetric Synthesis of Oxindoles Containing Trifluoromethylated Quaternary Stereogenic Centers.

An asymmetric palladium and copper co-catalyzed sequential Heck/Sonogashira reaction between o -iodoacrylanilides and terminal alkynes to synthesize chiral oxindoles was developed and can provide a general approach to access oxindole derivatives containing quaternary stereogenic centers including CF 3 -substituted ones.



D2 autoreceptor inhibition reveals oxygen-glucose deprivation-induced release of dopamine in guinea-pig cochlea

The pharmacology of the neurochemical transmission in the midbrain raphe nuclei of the rat.

Evidence was found for reciprocal interactions between serotonergic and glutamatergic as well as serotonerg and GABAergic innervations in the raphe nuclei and the close relation between 5-HT transporter and release-mediating 5- HT autoreceptors was shown by addition of L-deprenyl.

Serotonin modulates auditory information processing in the cochlear nucleus of the rat

5‐HT6 receptor antagonist SB‐271046 enhances extracellular levels of monoamines in the rat medial prefrontal cortex

The results of the present study support the rationale for the use of 5‐HT6 receptor antagonists in the treatment of cognitive dysfunction associated with psychiatric diseases.

Serotonergic innervation of the organ of Corti.

The presence and distribution of serotonin-containing fibres has been included in the long list of cochlear neuroactive substances, and its highly particular peripheral pattern of distribution together with the lack of response to sound stimulation could suggest that serotonergic fibres constitute a previously unknown co chlear innervation.