5-HT5A receptor localization in the rat spinal cord suggests a role in nociception and control of pelvic floor musculature.

@article{Doly20045HT5ARL,
  title={5-HT5A receptor localization in the rat spinal cord suggests a role in nociception and control of pelvic floor musculature.},
  author={St{\'e}phane Doly and Jacqueline Fischer and M. -J. Brisorgueil and Daniel Verg{\'e} and Marie Conrath},
  journal={The Journal of comparative neurology},
  year={2004},
  volume={476 4},
  pages={316-29}
}
The 5-HT5A receptor is a seven-transmembrane receptor negatively coupled to adenylate cyclase, whose activation opens K+ channels. The 5-HT5A receptor may thus exert an inhibitory effect on neuronal activity. However, the function of this receptor is still largely unknown, in particular at the spinal level, and this is partly due to lack of specific ligands. Immunocytochemistry using specific anti-5-HT5A antibodies reveals a particularly dense labeling in the two superficial layers of the… CONTINUE READING

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Neural control of the female urethral and anal rhabdosphincters and pelvic floor muscles.

American journal of physiology. Regulatory, integrative and comparative physiology • 2010

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