5-HT4 receptor antagonism does not affect motor and reward mechanisms in the rat.

@article{Reavill19985HT4RA,
  title={5-HT4 receptor antagonism does not affect motor and reward mechanisms in the rat.},
  author={Charlie Reavill and Jonathan P. Hatcher and Victor A Lewis and Graham J Sanger and Jim Hagan},
  journal={European journal of pharmacology},
  year={1998},
  volume={357 2-3},
  pages={115-20}
}
5-HT4 receptors are concentrated in areas of the brain which are rich in dopamine neuronal markers, which may suggest that they influence motor and reward processes. We tested this hypothesis by examining the effects of a 5-HT4 receptor antagonist, 8-amino-7-chloro-(N-butyl-4-piperidyl)methylbenzo-1,4-dioxan-5-car boxylate hydrochloride (SB-204070-A) on amphetamine- and nicotine-induced locomotor stimulation in intact rats. In rats with unilateral 6-hydroxydopamine-induced lesions of the… CONTINUE READING

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