5-HT4(a) Receptors Avert Opioid-Induced Breathing Depression Without Loss of Analgesia

@article{Manzke20035HT4aRA,
  title={5-HT4(a) Receptors Avert Opioid-Induced Breathing Depression Without Loss of Analgesia},
  author={Till Manzke and Ulf Guenther and Evgeni G. Ponimaskin and Miriam Haller and Mathias Dutschmann and Stephan W. Schwarzacher and Diethelm W. Richter},
  journal={Science},
  year={2003},
  volume={301},
  pages={226 - 229}
}
Opiates are widely used analgesics in anesthesiology, but they have serious adverse effects such as depression of breathing. This is caused by direct inhibition of rhythm-generating respiratory neurons in the Pre-Boetzinger complex (PBC) of the brainstem. We report that serotonin 4(a) [5-HT4(a)] receptors are strongly expressed in respiratory PBCneurons and that their selective activation protects spontaneous respiratory activity. Treatment of rats with a 5-HT4 receptor–specific agonist… 

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