5-HT3 receptors and the neural actions of alcohols: an increasingly exciting topic

@article{Lovinger19995HT3RA,
  title={5-HT3 receptors and the neural actions of alcohols: an increasingly exciting topic},
  author={David M. Lovinger},
  journal={Neurochemistry International},
  year={1999},
  volume={35},
  pages={125-130}
}
  • D. Lovinger
  • Published 1 August 1999
  • Medicine
  • Neurochemistry International
The role of GABAA receptors in mediating the effects of alcohol in the central nervous system.
  • M. Davies
  • Biology
    Journal of psychiatry & neuroscience : JPN
  • 2003
TLDR
Several aspects of GABAA receptor and ethanol interactions are reviewed, including the evidence for short- and long-term modulation of GabAA receptors by ethanol and evidence for a GAB AA receptor-related genetic component of alcoholism.
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TLDR
It is found that n-alcohols, depending on the carbon chain length, exert a dual action, potentiation and inhibition, on nnAChRs in primary cultured rat cortical neurons, suggesting that potentiating and inhibitory actions are exerted through two different binding sites.
Distinct Molecular Basis for Differential Sensitivity of the Serotonin Type 3A Receptor to Ethanol in the Absence and Presence of Agonist*
TLDR
It is reported that point mutations of the arginine at amino acid 222 in the N-terminal domain of the5-HT3A receptor can alter the EC50 value of the 5-HT concentration-response curve, suggesting that distinct molecular processes may determine the sensitivity of 5- HT3Areceptors to ethanol in the absence and presence of agonist.
5-HT3A Receptor Subunit is Required for 5-HT3 Antagonist-Induced Reductions in Alcohol Drinking
TLDR
Analysis of acute locomotor response to alcohol and alcohol consumption in a two-bottle home-cage procedure by congenic C57BL/6J mice with a targeted deletion of the 5- HT3A receptor subunit gene indicates that reduction of alcohol drinking produced by 5-HT3 antagonism is dependent on the presence of 5-ht3A-containing receptors.
Neurobiological alterations in alcohol addiction: a review.
TLDR
In this review different neurochemical alterations produced by ethanol are described and the serotonergic, noradrenergic, corticotropin-releasing factor and cannabinoid systems seem to play an important role in the neurobiology of alcoholism.
Neuronal Nicotinic Acetylcholine Receptors:Molecular Targets for Alcoholism andEthanol Reward: A Dissertation
TLDR
It is shown, for the first time, that a specific nAChR subtype, those that contain the α4 subunit (α4*), mediate voluntary ethanol consumption and reward and further supports the hypothesis that α4* nA ChRs are molecular targets for alcohol cessation therapies.
Neuropharmacology of alcohol addiction
TLDR
The activity of the mesolimbic dopaminergic system plays a crucial role during the initiation phase of alcohol consumption and the neurochemical substrates that are involved in the initiation and maintenance phase of an alcohol drinking behaviour are discussed.
Serotonin-3 receptors in the actions of alcohol, alcohol reinforcement, and alcoholism.
This article represents the proceedings of a symposium at the 2003 annual meeting of the Research Society on Alcoholism in Fort Lauderdale, FL. The organizers and chairs were William J. McBride and
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