5-HT3 receptors and the neural actions of alcohols: an increasingly exciting topic

@article{Lovinger19995HT3RA,
  title={5-HT3 receptors and the neural actions of alcohols: an increasingly exciting topic},
  author={David M. Lovinger},
  journal={Neurochemistry International},
  year={1999},
  volume={35},
  pages={125-130}
}
  • D. Lovinger
  • Published 1 August 1999
  • Medicine
  • Neurochemistry International
View on Elsevier
doi.org
186 Citations
Highly Influential Citations
4
Background Citations
65
Methods Citations
1
Results Citations
1

186 Citations

Citation Type

Citation Type

The role of GABAA receptors in mediating the effects of alcohol in the central nervous system.
  • M. Davies
  • Biology
    Journal of psychiatry & neuroscience : JPN
  • 2003
TLDR
Several aspects of GABAA receptor and ethanol interactions are reviewed, including the evidence for short- and long-term modulation of GabAA receptors by ethanol and evidence for a GAB AA receptor-related genetic component of alcoholism.
Dual action of n-alcohols on neuronal nicotinic acetylcholine receptors.
TLDR
It is found that n-alcohols, depending on the carbon chain length, exert a dual action, potentiation and inhibition, on nnAChRs in primary cultured rat cortical neurons, suggesting that potentiating and inhibitory actions are exerted through two different binding sites.
Distinct Molecular Basis for Differential Sensitivity of the Serotonin Type 3A Receptor to Ethanol in the Absence and Presence of Agonist*
TLDR
It is reported that point mutations of the arginine at amino acid 222 in the N-terminal domain of the5-HT3A receptor can alter the EC50 value of the 5-HT concentration-response curve, suggesting that distinct molecular processes may determine the sensitivity of 5- HT3Areceptors to ethanol in the absence and presence of agonist.
5-HT3A Receptor Subunit is Required for 5-HT3 Antagonist-Induced Reductions in Alcohol Drinking
TLDR
Analysis of acute locomotor response to alcohol and alcohol consumption in a two-bottle home-cage procedure by congenic C57BL/6J mice with a targeted deletion of the 5- HT3A receptor subunit gene indicates that reduction of alcohol drinking produced by 5-HT3 antagonism is dependent on the presence of 5-ht3A-containing receptors.
Neurobiological alterations in alcohol addiction: a review.
TLDR
In this review different neurochemical alterations produced by ethanol are described and the serotonergic, noradrenergic, corticotropin-releasing factor and cannabinoid systems seem to play an important role in the neurobiology of alcoholism.
Neuronal Nicotinic Acetylcholine Receptors:Molecular Targets for Alcoholism andEthanol Reward: A Dissertation
TLDR
It is shown, for the first time, that a specific nAChR subtype, those that contain the α4 subunit (α4*), mediate voluntary ethanol consumption and reward and further supports the hypothesis that α4* nA ChRs are molecular targets for alcohol cessation therapies.
Effects of l-histidine and histamine H3 receptor modulators on ethanol-induced sedation in mice
Neuropharmacology of alcohol addiction
TLDR
The activity of the mesolimbic dopaminergic system plays a crucial role during the initiation phase of alcohol consumption and the neurochemical substrates that are involved in the initiation and maintenance phase of an alcohol drinking behaviour are discussed.
Cocaine inhibits 5-HT3 receptor function in neurons from transgenic mice overexpressing the receptor.
Serotonin-3 receptors in the actions of alcohol, alcohol reinforcement, and alcoholism.
This article represents the proceedings of a symposium at the 2003 annual meeting of the Research Society on Alcoholism in Fort Lauderdale, FL. The organizers and chairs were William J. McBride and…
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 47 REFERENCES
The role of 5-HT3 receptors in drug dependence.
  • K. Grant
  • Biology, Psychology
    Drug and alcohol dependence
  • 1995
5-HT3 receptors are membrane ion channels
TLDR
The first recordings of currents through single ion channels activated by 5-HT3 receptors are reported, in excised membrane patches from neurons of the guinea pig submucous plexus, implying a role for 5- HT, and perhaps other amines, as a 'fast' synaptic transmitter.
Ethanol inhibition of nicotinic acetylcholine type alpha 7 receptors involves the amino-terminal domain of the receptor.
TLDR
Ethanol was found to inhibit the function of this chimeric receptor in a manner similar to that of nACh alpha 7 receptors, suggesting that the amino-terminal domain of the receptor is involved in the inhibition.
The 5-HT3B subunit is a major determinant of serotonin-receptor function
TLDR
Surprisingly, the M2 region of the 5-HT3B subunit lacks any of the structural features that are known to promote the conductance of related receptors, and will be a valuable resource for defining the molecular mechanisms of ion-channel function.
Primary structure and functional expression of the 5HT3 receptor, a serotonin-gated ion channel.
TLDR
A complementary DNA clone containing the coding sequence of one of these rapidly responding channels, a 5HT3 subtype of the serotonin receptor, has been isolated by screening a neuroblastoma expression library for functional expression of serotonin-gated currents in Xenopus oocytes.
Serotonin and alcohol intake, abuse, and dependence: Findings of animal studies
Activation of 5-HT3 receptor by 1-phenylbiguanide increases dopamine release in the rat nucleus accumbens
Serotonin and alcohol intake, abuse, and dependence: Clinical evidence
Alcohols and anesthetics enhance the function of 5-hydroxytryptamine3 receptors expressed in Xenopus laevis oocytes.
  • T. Machu, R. Harris
  • Biology
    The Journal of pharmacology and experimental therapeutics
  • 1994
TLDR
The results suggest that alcohols and volatile anesthetics have similar actions on 5-HT3 receptor function, which is in agreement with results of studies with other members of the superfamily of ligandgated ion channels.
Pharmacologic characteristics of potentiation of 5-HT3 receptors by alcohols and diethyl ether in NCB-20 neuroblastoma cells.
  • Q. Zhou, D. Lovinger
  • Biology, Chemistry
    The Journal of pharmacology and experimental therapeutics
  • 1996
TLDR
The absence of competitive interactions among alcohols indicates that a single "alcohol receptor" cannot be defined using established pharmacologic approaches, and is most consistent with the idea that alcohols interact with several hydrophobic sites associated with the 5-HT3 receptor.
...
1
2
3
4
5
...