5-HT2C receptors are involved in the discriminative stimulus effects of citalopram in rats

@article{Millan19995HT2CRA,
  title={5-HT2C receptors are involved in the discriminative stimulus effects of citalopram in rats},
  author={Mark John Millan and Sylvie Girardon and Anne Dekeyne},
  journal={Psychopharmacology},
  year={1999},
  volume={142},
  pages={432-434}
}
 Rats were trained on a fixed ratio 10, food-reinforced schedule to recognize a discriminative stimulus (DS) elicited by the selective serotonin (5-HT) reuptake inhibitor (SSRI), citalopram (2.5 mg/kg, IP). The preferential, high efficacy agonist at 5-HT2C receptors, Ro60-0175, dose-dependently generalized to citalopram with an ED50 of 0.3 mg/kg, IP. Further, the selective 5-HT2C receptor antagonist, SB242,084, dose-dependently (ED50=0.1 mg/kg, IP) blocked the citalopram DS. These data suggest… CONTINUE READING

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