5-HT2C receptor agonists attenuate pain-related behaviour in a rat model of trigeminal neuropathic pain.

@article{Nakai20105HT2CRA,
  title={5-HT2C receptor agonists attenuate pain-related behaviour in a rat model of trigeminal neuropathic pain.},
  author={Kunihiro Nakai and Aya Nakae and Sosuke Oba and Takashi Mashimo and Koichi Ueda},
  journal={European journal of pain},
  year={2010},
  volume={14 10},
  pages={999-1006}
}
Peripheral branches of the trigeminal nerve may be damaged during maxillofacial injury or surgical procedures and trigeminal trauma may induce severe pain that is very challenging to treat. Chronic constriction injury to the infraorbital nerve (ION-CCI) by loose ligatures has proven a useful model for some types of trigeminal neuropathic pain disorder. Using ION-CCI rats, we examined the antiallodynic effects of intrathecally administered agents which are selective for 5-HT2C receptors… CONTINUE READING