5-HT2C receptor agonists as potential drugs for the treatment of obesity.

@article{Bickerdike20035HT2CRA,
  title={5-HT2C receptor agonists as potential drugs for the treatment of obesity.},
  author={Michael J. Bickerdike},
  journal={Current topics in medicinal chemistry},
  year={2003},
  volume={3 8},
  pages={
          885-97
        }
}
An association between the brain serotonin (5-HT) system and feeding has been postulated since the 1970's but it has only been in recent years that the nature of 5-HT-mediated hypophagia has become well understood, and the receptor subtypes responsible for the effect better defined. The invention and utilisation of subtype-selective 5-HT receptor antagonists has demonstrated that the 5-HT(2C) receptor is of paramount importance in this regard. Importantly, ethological studies of animal… CONTINUE READING
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