5-HT2A receptors in the feline brain: 123I-5-I-R91150 kinetics and the influence of ketamine measured with micro-SPECT.

@article{Waelbers20135HT2ARI,
  title={5-HT2A receptors in the feline brain: 123I-5-I-R91150 kinetics and the influence of ketamine measured with micro-SPECT.},
  author={Tim Waelbers and Ingeborgh E Polis and Simon T Vermeire and Andr{\'e} A. Dobbeleir and Jos Leon Henri Eersels and Bart De Spiegeleer and Kurt R Audenaert and Guido Slegers and Kathelijne Y Peremans},
  journal={Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year={2013},
  volume={54 8},
  pages={1428-33}
}
UNLABELLED Subanesthetic doses of ketamine can be used as a rapid-acting antidepressant in patients with treatment-resistant depression. Therefore, the brain kinetics of (123)I-5-I-R91150 (4-amino-N-[1-[3-(4-fluorophenyl)propyl]-4-methylpiperidin-4-yl]-5-iodo-2-methoxybenzamide) and the influence of ketamine on the postsynaptic serotonin-2A receptor (5-hydroxytryptamine-2A, or 5-HT2A) status were investigated in cats using micro-SPECT. METHODS This study was conducted on 6 cats using the… CONTINUE READING
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The influence of ketamine on the regional cerebral perfusion and on the serotonin-2A receptor in the canine brain

T Waelbers, I Polis, S Vermeire
Vet Anaesth Analg • 2013
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