5-HT2A receptor subtype in the peripheral branch of sensory fibers is involved in the potentiation of inflammatory pain in rats

@article{Okamoto20025HT2ARS,
  title={5-HT2A receptor subtype in the peripheral branch of sensory fibers is involved in the potentiation of inflammatory pain in rats},
  author={Keiichiro Okamoto and Hiroki Imbe and Yoshihiro Morikawa and Masayuki Itoh and Emiko Senba},
  journal={PAIN},
  year={2002},
  volume={99},
  pages={133-143}
}
One of the major serotonin (5-HT) receptor subtypes expressed in the rat dorsal root ganglion (DRG) neurons is the 5-HT2A receptor. We have previously shown that 5-HT2A receptors in the peripheral sensory terminals are responsible for 5-HT-induced pain and hyperalgesia. In the present study, we characterized neurons expressing 5-HT2A receptors in the rat DRG neurons by means of in situ hybridization, immunohistochemistry, reverse transcription-polymerase chain reaction (RT-PCR) and behavioral… CONTINUE READING

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