5-HT2A receptor-stimulated phosphoinositide hydrolysis in the stimulus effects of hallucinogens.

@article{Rabin20025HT2ARP,
  title={5-HT2A receptor-stimulated phosphoinositide hydrolysis in the stimulus effects of hallucinogens.},
  author={Richard A. Rabin and Meredith Regina and Mireille M Doat and Jerrold C. Winter},
  journal={Pharmacology, biochemistry, and behavior},
  year={2002},
  volume={72 1-2},
  pages={29-37}
}
The role of 5-HT2A-mediated stimulation of phosphoinositide hydrolysis in the discriminative effects of hallucinogens was investigated in PC12 cells stably expressing the rat 5-HT2A receptor (PC12-5-HT2A cells). The hallucinogenic compounds, D-lysergic acid diethylamide (LSD), (-)2,5-dimethoxy-4-methylamphetamine (DOM), psilocybin, N,N-dimethyltryptamine (DMT), 5-methoxy-N,N-dimethyltryptamine (MDMT) and N,N-diethyltryptamine (DET), all caused a concentration-dependent increase in the… CONTINUE READING

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