5-HT2A receptor gene promoter polymorphism –1438A/G and bipolar disorder

@article{Chee20015HT2ARG,
  title={5-HT2A receptor gene promoter polymorphism –1438A/G and bipolar disorder},
  author={I. S. Chee and S. W. Lee and J. L. Kim and S. K. Wang and Y. O. Shin and S C Shin and Y. H. Lee and Hyeoncheol Hwang and Mi Rang Lim},
  journal={Psychiatric Genetics},
  year={2001},
  volume={11},
  pages={111-114}
}
Genetic factors, such as the genes involved in the serotonin pathway, probably play an important role in the pathogenesis of bipolar disorder, and serotonin type 2A (5-HT2A) receptor gene promoter polymorphism –1438A/G has been reported. This study investigated the association between –1438A/G polymorphism of 5-HT2A receptor gene promoter and bipolar disorder in a Korean population. Using the polymerase chain reaction, –1438A/G polymorphism typed in 142 patients with bipolar disorder and in 148… 

Association between Serotonin-Related Polymorphisms in 5HT2A, TPH1, TPH2 Genes and Bipolar Disorder in Korean Population

There was a trend towards association between 5-HT2A -1438A/G polymorphism and psychotic symptom in bipolar disorder, but the statistically significant association between three polymorphisms and bipolar disorder was failed to found.

Serotonin Receptor 2A Gene Polymorphism (–1438A/G) and Short-Term Treatment Response to Citalopram

The results suggest that the G allele of the –1438A/G polymorphism in the 5-HTR2A gene is associated with MDD, and that patients with –1437G/–1438G have a better response to citalopram treatment than patients with–1437A/– 1438A or –1434A/-1434G.

Linkage and association between serotonin 2A receptor gene polymorphisms and bipolar I disorder

  • S. RanadeH. Mansour V. Nimgaonkar
  • Biology
    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • 2003
The results support an etiological role for HTR2A in BD1 and suggest significant linkage and associations with 1354C/T, as well as haplotypes bearing this SNP, consistent with haplotype‐based differences.

Association Study of a Serotonin Receptor 2A Gene -1438A/G Polymorphism and Anxiety-Related Traits

Findings suggest that the -1438A/G polymorphism of 5HTR2A might not be associated with anxiety sensitivity or trait anxiety.

Family-based association study of the serotonin-2A receptor gene (5-HT2A) and bipolar disorder

Results of this study suggest that the 5-HT2A is unlikely to play a major role in the genetic susceptibility to BP, and future studies will be directed towards increasing sample size, focusing on subtypes of BP or biochemical measures as phenotypes, and investigating other polymorphisms of 5- HT2A to provide more information at the DNA level.

Associations between serotonin-related gene polymorphisms and panic disorder.

Findings indicate that genetic variants conceivably related to lower 5-HT neurotransmission may be involved in the development of PD.

Genes in the serotonin pathway are associated with bipolar affective disorder in a Han Chinese population

The results indicate that the HTR2A and TPH2 genes in the serotonin pathway play important roles in susceptibility to BP-I, both genotype-wise and allele-wise.

Serotonin gene polymorphisms and bipolar I disorder: Focus on the serotonin transporter

It is reasoned that other polymorphism/s may contribute to the associations and the inconsistencies may be due to variations in linkage disequilibrium patterns between samples, and conducted LD analyses, as well as association and linkage using 12 polymorphisms, including 5HTTLPR.
...

References

SHOWING 1-10 OF 38 REFERENCES

Serotonin2A receptor gene polymorphism in mood disorders

5‐HT2A receptor gene promoter polymorphism – 1438G/A and mood disorders

The polymorphism of 5-HT2A receptor promoter polymorphism was studied in 95 Japanese patients with mood disorders and 106 healthy Japanese controls and the genotype frequencies did not differ according to the subdiagnosis, age of onset, family history of psychiatric illness or suicide attempts.

Association between seasonal affective disorder and the 5-HT2A promoter polymorphism, −1438G/A

It is shown that the −1438g/a 5-ht2A promoter variant is associated with SAD but not with seasonality, and it is suggested that the association may instead be with the depressive symptoms of SAD.

Characterization of the human 5-HT2A receptor gene promoter

  • Q. ZhuKevin ChenJ. Shih
  • Biology
    The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1995
Transfection of chimeric growth hormone plasmids containing various DNA fragments into 5-HT2AR-positive human cell lines showed that the 0.74 kb HaeIII/PvuII fragment, which encompasses the initiation sites between - 1157 and -1127 and 5′ of the downstream initiation site (at -496), exhibited significant promoter activity.

Serotonin receptor subtypes : pharmacological significance and clinical implications

The 5-HT receptors modulate glutamate release in cerebellum and cholecystokinin release in nucleus accumbens and possible relevance to cerebellar ataxias and to anxiety, M. Raiteri et al serotonin and eating disorders - pharmacological relationships.

Regulation of rat 5-hydroxytryptamine type 2 receptor gene activity: identification of cis elements that mediate basal and 5-hydroxytryptamine-dependent gene activation.

Results suggest that the basal promoter unit includes bp -25 to 1 and that upstream sequences act to repress basal promoter activity.

5-HT2 receptor antagonism and slow-wave sleep in major depression.

The effects of a single dose or ritanserin (5 mg) on sleep electroencephalography in 18 major depressed patients and in 10 control subjects were explored, in agreement with a potential 5-HT disturbance, particularly at the 5- HT2 receptor level, in some clinical forms of depression.