5-HT2A receptor gene promoter polymorphism –1438A/G and bipolar disorder

  title={5-HT2A receptor gene promoter polymorphism –1438A/G and bipolar disorder},
  author={I. S. Chee and S. W. Lee and J. L. Kim and S. K. Wang and Y. O. Shin and S C Shin and Y. H. Lee and Hyeoncheol Hwang and Mi Rang Lim},
  journal={Psychiatric Genetics},
Genetic factors, such as the genes involved in the serotonin pathway, probably play an important role in the pathogenesis of bipolar disorder, and serotonin type 2A (5-HT2A) receptor gene promoter polymorphism –1438A/G has been reported. This study investigated the association between –1438A/G polymorphism of 5-HT2A receptor gene promoter and bipolar disorder in a Korean population. Using the polymerase chain reaction, –1438A/G polymorphism typed in 142 patients with bipolar disorder and in 148… 

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    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • 2003
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Association Study of a Serotonin Receptor 2A Gene -1438A/G Polymorphism and Anxiety-Related Traits

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Genes in the serotonin pathway are associated with bipolar affective disorder in a Han Chinese population

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Serotonin2A receptor gene polymorphism in mood disorders

5‐HT2A receptor gene promoter polymorphism – 1438G/A and mood disorders

The polymorphism of 5-HT2A receptor promoter polymorphism was studied in 95 Japanese patients with mood disorders and 106 healthy Japanese controls and the genotype frequencies did not differ according to the subdiagnosis, age of onset, family history of psychiatric illness or suicide attempts.

Association between seasonal affective disorder and the 5-HT2A promoter polymorphism, −1438G/A

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Characterization of the human 5-HT2A receptor gene promoter

  • Q. ZhuKevin ChenJ. Shih
  • Biology
    The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1995
Transfection of chimeric growth hormone plasmids containing various DNA fragments into 5-HT2AR-positive human cell lines showed that the 0.74 kb HaeIII/PvuII fragment, which encompasses the initiation sites between - 1157 and -1127 and 5′ of the downstream initiation site (at -496), exhibited significant promoter activity.

Serotonin receptor subtypes : pharmacological significance and clinical implications

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5-HT2 receptor antagonism and slow-wave sleep in major depression.

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