5-HT2A receptor antagonists inhibit potassium-stimulated gamma-aminobutyric acid release in rat frontal cortex.

@article{Cozzi19965HT2ARA,
  title={5-HT2A receptor antagonists inhibit potassium-stimulated gamma-aminobutyric acid release in rat frontal cortex.},
  author={Nicholas V Cozzi and David E. Nichols},
  journal={European journal of pharmacology},
  year={1996},
  volume={309 1},
  pages={25-31}
}
Several drugs selective for the serotonin 5-HT2A receptor were tested for their effects on spontaneous and K(+)-evoked [3H] gamma-aminobutyric acid (GABA) release from slices of rat frontal cortex. Under K+ stimulation, the antagonists ketanserin, spiperone, R-(+)-alpha-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenethyl)]- 4-piperidinemethanol (MDL 100,907) and ritanserin inhibited GABA release by 12-31%. Rats were treated with the serotonin-depleting agent para-chlorophenylalanine and with the… CONTINUE READING

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