5-HT2 receptor-mediated reversal of the inhibition of hippocampal long-term potentiation by acute inescapable stress

@article{Ryan20085HT2RR,
  title={5-HT2 receptor-mediated reversal of the inhibition of hippocampal long-term potentiation by acute inescapable stress},
  author={Benedict K. Ryan and Roger Anwyl and Michael J. Rowan},
  journal={Neuropharmacology},
  year={2008},
  volume={55},
  pages={175-182}
}
The serotonergic system is known to modulate and mediate many of the central nervous system effects of stress. Here we investigated the ability of serotonergic agents to reverse the inhibition of the induction of hippocampal long-term potentiation (LTP) caused by prior exposure to inescapable stress. Elevated platform stress prevented the induction of LTP in the CA1 area of anaesthetized rats. An agent that increases extracellular 5-HT concentration, fenfluramine (5 mg/kg, i.p.) enabled the… Expand
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References

SHOWING 1-10 OF 76 REFERENCES
Overcoming the Effects of Stress on Synaptic Plasticity in the Intact Hippocampus: Rapid Actions of Serotonergic and Antidepressant Agents
TLDR
Findings show that antidepressants have rapid and powerful interactions with the mechanisms controlling the persistence of the block of LTP by inescapable stress. Expand
Fluvoxamine suppresses the long-term potentiation in the hippocampal CA1 field of anesthetized rats: an effect mediated via 5-HT1A receptors
TLDR
Fluvoxamine-induced suppression of LTP was completely reversed by the 5-HT(1A) receptor antagonist NAN-190, and the inhibitory effect of fluvoxamines on LTP induction is mediated via 5- HT( 1A) receptors. Expand
The 5-hydroxytryptamine4 receptor exhibits frequency-dependent properties in synaptic plasticity and behavioural metaplasticity in the hippocampal CA1 region in vivo.
TLDR
Application of the 5-HT4 receptor agonist completely blocks learning-induced depotentiation of LTP in the hippocampal CA1 region of freely moving rats, suggesting a role for 5- HT4 receptors in behavioural metaplasticity and a key role in the regulation of synaptic plasticity and the determination of the particular properties of stored synaptic information. Expand
Effects of 5-HT3 receptor antagonism on hippocampal theta rhythm, memory, and LTP induction in the freely moving rat
  • U. Staubli, FB Xu
  • Chemistry, Medicine
  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1995
TLDR
Ondansetron, a potent and selective antagonist of the 5- HT3 receptor, was examined on frequency of the hippocampal theta rhythm, induction of LTP in field CA1 of freely moving rats, and retention of olfactory and spatial memory in tasks known to depend on an intact hippocampus. Expand
Differential characteristics of endogenous serotonin-mediated synaptic transmission in the hippocampal CA1 and CA3 fields of anaesthetized rats
TLDR
Electrophysiological approaches used to elucidate the effects of a selective 5-HT reuptake inhibitor, fluvoxamine, on synaptic transmission by determining the population spike amplitude revealed that characteristics of synaptic transmission mediated via 5- HT receptors differ between the CA1 and CA3 fields. Expand
Tianeptine stimulates uptake of 5-hydroxytryptamine in vivo in the rat brain
TLDR
The fact that both inhibitors of the uptake of 5-HT and tianeptine which, in contrast, enhanced the in vivo uptake of5-HT, are potent antidepressants, challenges the current hypothesis on the central mechanisms of action of these drugs. Expand
5-HT2A Receptor-Mediated Regulation of Brain-Derived Neurotrophic Factor mRNA in the Hippocampus and the Neocortex
TLDR
The results of this study raise the possibility that regulation of BDNF expression by hallucinogenic 5-HT2Areceptor agonists leads to adaptations of synaptic strength in the hippocampus and the neocortex that may mediate some of the acute and long-term behavioral effects of these agents. Expand
Serotonergic Regulation of Acetylcholine Release in Rat Frontal Cortex
TLDR
It is indicated that fenfluramine increases cortical acetylcholine release in vivo by its ability to enhance serotonin transmission and that serotonin produces these effects at least in part via actions at serotonin 5‐HT2A receptors. Expand
Effects of acute and chronic tianeptine administration on serotonin outflow in rats: comparison with paroxetine by using in vivo microdialysis.
TLDR
In vivo data indicate that tianeptine and paroxetine do not exert a similar in vivo effect on the serotonergic system in rat brain and drug challenge did not alter area under the curve values. Expand
Intravenous administration of the serotonin agonist m-chlorophenylpiperazine (mCPP) increases extracellular serotonin in the diencephalon of awake rats
TLDR
Results indicate that mCPP increases extracellular 5-HT in rat brain by a presynaptic mechanism involving5-HT transporters, and suggest the possibility that m CPP exhibits indirect agonist properties in human brain. Expand
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5
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