5-HT2 receptor antagonists and migraine therapy

@article{Mylecharane20045HT2RA,
  title={5-HT2 receptor antagonists and migraine therapy},
  author={Ewan J. Mylecharane},
  journal={Journal of Neurology},
  year={2004},
  volume={238},
  pages={S45-S52}
}
Summary5-Hydroxytryptamine (5-HT; serotonin) has been implicated in the pathophysiology of migraine, and several drugs with potent 5-HT2 receptor blocking activity (methysergide, pizotifen, cyproheptadine and mianserin) have been recognized as being clinically effective in migraine prophylaxis, although the selective 5-HT2 receptor antagonist ketanserin (the principal agent used to identify 5-HT2 receptor-mediated actions) seems to be ineffective in migraine. Pizotifen is the most widely used 5… 
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The compound m-chlorophenylpiperazine (mCPP), which is known to trigger migraine-like head pain in some subjects, was evaluated for its ability to induce dural plasma protein extravasation (PPE) in
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Evaluating the influence of [K]o on the 5-HT2A receptor-mediated effects onbasal respiratory activity and the phases of the hypoxic ventilatory response (HVR), including ischemia-induced gasping using an arterially-perfused adult rat preparation demonstrates an important role for 5- HT2A receptors in respiratory control, and indicates its independence on [K ]o.
Pharmacology and Molecular Identity of Serotonin Receptor in Bivalve Mollusks
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The present review pays a special attention to future research perspectives to better understand 5-HT regulation of reproduction in bivalves, which can provide satisfactory knowledge to elucidate reproductive disorders associated with dysfunctions of the neurotransmitter system.
Pharmacological analysis of red-wine-induced migrainous headaches
TLDR
It seems that different pharmacological receptors may be responsible for headaches in different patients, as plasma levels of the enzyme diamine oxidase were lower in all migraine patients, whether or not they were sensitive to red wine.
The vasomotor effects of 5-hydroxytryptamine on equine basilar arteries In vitro
TLDR
The findings of this study indicate that 5-HT1 and5-HT2 receptors are located in equine basilar arterial smooth muscle cells, and that stimulation of these receptors results in contraction.
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