5-HT2 receptor antagonism and slow-wave sleep in major depression.

  title={5-HT2 receptor antagonism and slow-wave sleep in major depression.},
  author={Luc Staner and Chantal Kempenaers and M P Simonnet and L Fransolet and Julien Mendlewicz},
  journal={Acta psychiatrica Scandinavica},
  volume={86 2},
Specific sleep disturbances such as reduced slow-wave sleep (SWS) and decreased serotonergic (5-HT) activity have been observed in depressive disorders. Ritanserin, a specific 5-HT2 receptor antagonist, has been shown to increase SWS in healthy subjects. This study explored the effects of a single dose or ritanserin (5 mg) on sleep electroencephalography in 18 major depressed patients and in 10 control subjects. Ritanserin affected SWS differently in the two groups. Although stage 3 increased… CONTINUE READING


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