5-HT2 receptor activation in the midbrain periaqueductal grey (PAG) reduces anxiety-like behaviour in mice

@article{NunesdeSouza20085HT2RA,
  title={5-HT2 receptor activation in the midbrain periaqueductal grey (PAG) reduces anxiety-like behaviour in mice},
  author={Vanessa Nunes-de-Souza and Ricardo L. Nunes‐de‐Souza and Robert John Rodgers and Azair Canto-de-Souza},
  journal={Behavioural Brain Research},
  year={2008},
  volume={187},
  pages={72-79}
}
It is widely acknowledged that the indoleamine neurotransmitter serotonin (5-HT) plays a dual role in the regulation of anxiety, a role that in part depends upon neuroanatomical locus of action. Thus, whereas stimulation of 5-HT 1A or 5-HT2 receptors in the limbic forebrain (amygdala, hippocampus) enhances anxiety-like responding in rodents, activation of corresponding receptor populations in the midbrain periaqueductal grey (PAG) more often than not reduce anxiety-like behaviour. The present… Expand
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