5-HT2 and D2 dopamine receptor occupancy in the living human brain

@article{Nyberg19935HT2AD,
  title={5-HT2 and D2 dopamine receptor occupancy in the living human brain},
  author={Svante Nyberg and Lars Farde and Lars Ove Eriksson and Christer Halldin and Bo Eriksson},
  journal={Psychopharmacology},
  year={1993},
  volume={110},
  pages={265-272}
}
It has been suggested that a combined blockade of 5-HT2 and D2 dopamine receptors may be superior to D2 dopamine antagonists alone in the treatment of schizophrenia. Risperidone, which has a high affinity for 5-HT2 and D2 dopamine receptors in vitro, is a new antipsychotic drug that has been developed according to this hypothesis. The aim of this study was to examine if risperidone indeed induces 5-HT2 and D2 dopamine receptor occupancy in vivo in humans. Central receptor occupancy was examined… CONTINUE READING