5-HT1D-like receptors inhibit the release of endogenously formed [3H]GABA in human, but not in rabbit, neocortex

  title={5-HT1D-like receptors inhibit the release of endogenously formed [3H]GABA in human, but not in rabbit, neocortex},
  author={Thomas J. Feuerstein and Holger H{\"u}ring and Vera van Velthoven and Carl H. L{\"u}cking and Georg Bernhard Landwehrmeyer},
  journal={Neuroscience Letters},

Modulation of cortical acetylcholine release by serotonin: the role of substance P interneurons

Close links between cholinergic afferents, SP interneurons and 5-HT2 receptors are suggested, which might help to explain early pathological changes in Alzheimer's disease.

Serotonin Modifies the Neuronal Inhibitory Responses to γ-Aminobutyric Acid in the Red Nucleus: A Microiontophoretic Study in the Rat

5-HT is able to modulate GABA-evoked responses in RN neurons by acting on both 5- HT(1A and 5-HT(2A) receptors, and the functional significance of a serotonergic control on GABAergic inhibitory effects in RN is discussed.

5-HT Receptor Regulation of Neurotransmitter Release

This review focuses on the function of presynaptic 5-hydroxytryptamine (5-HT) heteroreceptors on axon terminals of central cholinergic, dopaminergic, noradrenergic, or GABAergic neurons and the role of GABAergic interneurons expressing 5-HT heteroreCEPTors in the regulation of acetylcholine, dopamine, or nor adrenaline release.

Pharmacological diversity between native human 5‐HT1B and 5‐HT1D receptors sited on different neurons and involved in different functions

It is concluded that native h5‐HT1B and h5-HT1D receptors exhibit a hitherto unexpected pharmacological diversity.

The cardiovascular regulatory role of 5-HT in the nucleus tractus solitarius

Preliminary data from rats with heart failure induced by coronary artery ligation found that glutamate and 5-HT transmission to be augmented within the NTS, suggesting that5-HT may act, in part, as a volume transmitter in the NTS.

A review of central 5-HT receptors and their function

The 5-HT1B receptor - a potential target for antidepressant treatment

The main focus of this review is the role of 5-HT1BR in relation to MDD and its treatment, although studies of5-HT 1BR in obsessive-compulsive disorder, alcohol dependence, and cocaine dependence are also reviewed.



Species differences in presynaptic serotonin autoreceptors: mainly 5-HT1B but possibly in addition 5-HT1D in the rat, 5-HT1D in the rabbit and guinea-pig brain cortex

The results confirm the view that the serotonin axons of rat brain possess 5-HT1B autoreceptors, and give additional credence to previous suggestions that, in the rabbit and guinea-pig, the autoreCEPTors are 5- HT1D.

Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase.

  • N. AdhamH. Kao T. Branchek
  • Biology, Chemistry
    Proceedings of the National Academy of Sciences of the United States of America
  • 1993
Competition studies revealed the following rank order of potencies for serotonergic ligands: 5-HT > sumatriptan >> 5-carboxyamidotryptamine > 8-hydroxy-2(di-1-propylamino)tetralin > spiperone.

Human serotonin 1D receptor is encoded by a subfamily of two distinct genes: 5-HT1D alpha and 5-HT1D beta.

Both receptors exhibit high-affinity binding of sumatriptan, a new anti-migraine medication, and thus are candidates for the pharmacological site of action of this drug.

Non 5‐HT1A/5‐HT1C[3H]5‐HT binding sites in the hamster, opossum, and rabbit brain show similar regional distribution but different sensitivity to β‐adrenoceptor antagonists

Investigation of the distribution and pharmacological profile of non 5‐ HT1A/5‐HT1C[3H]5‐hydroxytryptamine binding sites in the brain of rabbits, hamsters and opossums indicates that non 5-HT1A or 5‐HT3H1C binding sites display a high affinity for these agents in a particular rodent suborder as well as in opossum, a phylogenetically unrelated species.

Endogenous Noradrenaline Activates α2‐Adrenoceptors on Serotonergic Nerve Endings in Human and Rat Neocortex

Investigation of α2‐heteroreceptors in human neocortex found they can be activated by endogenous NA released from neighboring noradrenergic fibers, and regulatory processes analogous to those in rats probably occur in humans as well.