5-HT1C receptor antagonists have anxiolytic-like actions in the rat social interaction model

@article{Kennett20055HT1CRA,
  title={5-HT1C receptor antagonists have anxiolytic-like actions in the rat social interaction model},
  author={Guy A. Kennett},
  journal={Psychopharmacology},
  year={2005},
  volume={107},
  pages={379-384}
}
  • G. Kennett
  • Published 2005
  • Psychology, Medicine
  • Psychopharmacology
The effects of a range of 5-HT receptor antagonists were examined in an animal model of anxiety — the social interaction test. Six antagonists with high affinity for 5-HT1C receptors; mianserin, (+) mianserin, 1-naphthyl piperazine, ICI 169 369, pizotifen and LY 53857 all increased the time spent in active social interaction by pairs of weight-matched rats under high light unfamiliar conditions. As locomotion was only increased by 1-NP and then only at high doses, the effect of the drugs is… Expand
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