5-HT1B receptors modulate components of satiety in the rat: behavioural and pharmacological analyses of the selective serotonin1B agonist CP-94,253

@article{Lee20025HT1BRM,
  title={5-HT1B receptors modulate components of satiety in the rat: behavioural and pharmacological analyses of the selective serotonin1B agonist CP-94,253},
  author={Michelle D. Lee and Guy A. Kennett and Colin T. Dourish and Peter G. Clifton},
  journal={Psychopharmacology},
  year={2002},
  volume={164},
  pages={49-60}
}
Abstract Rationale. 5-HT1B receptors are thought to be one of the receptor subtypes that mediate the inhibitory control of serotonin on food intake and satiety. Objective. To use the selective 5-HT1B receptor agonist, CP-94,253 as a probe of 5-HT1B receptor function in feeding behaviour, and to confirm the pharmacological selectivity of CP-94,253-induced hypophagia with a range of antagonists. Methods. Dose-response functions for CP-94,253 (0, 1.25, 2.5, 5.0 mg/kg; IP) were determined in… 

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The 5-HT1B receptor agonist CP-94,253 reduces food intake and preserves the behavioural satiety sequence

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