5-HT1B receptors modulate components of satiety in the rat: behavioural and pharmacological analyses of the selective serotonin1B agonist CP-94,253

  title={5-HT1B receptors modulate components of satiety in the rat: behavioural and pharmacological analyses of the selective serotonin1B agonist CP-94,253},
  author={Michelle D. Lee and Guy A. Kennett and Colin T. Dourish and Peter G. Clifton},
Abstract Rationale. 5-HT1B receptors are thought to be one of the receptor subtypes that mediate the inhibitory control of serotonin on food intake and satiety. Objective. To use the selective 5-HT1B receptor agonist, CP-94,253 as a probe of 5-HT1B receptor function in feeding behaviour, and to confirm the pharmacological selectivity of CP-94,253-induced hypophagia with a range of antagonists. Methods. Dose-response functions for CP-94,253 (0, 1.25, 2.5, 5.0 mg/kg; IP) were determined in… 

Serotonin 1B and 2C receptor interactions in the modulation of feeding behaviour in the mouse

5-HT2C-R and 5-HT1B-R activation are each sufficient to induce a hypophagic response, however, concurrent 5- HT2c-R inactivation can potentiate the hypophotic response to 5-ht1b-Ractivation, consistent with an inhibitory role for the 5-hydroxytryptamine-based response in behaviour mediated by the activation of other 4-HT receptors.

Effects of a selective 5-HT1B receptor agonist and antagonists in animal models of anxiety and depression

The results indicate that the selective agonist (CP 94253) and antagonists (SB 216641 and GR 127935) of 5-HT1B receptors produce effects that are characteristic of anxiolytics, in the preclinical models used; however, CP 94253 also behaves like an antidepressant drug.

Tonic regulation of satiety by 5‐HT1B receptors in the mouse: converging evidence from behavioural and c‐fos immunoreactivity studies?

The results suggest that the activation of 5‐HT1B receptors is an important component of endogenous satiation mechanisms in the mouse.

The Role of Serotonin in Eating Behavior: Focus on 5-HT2C Receptors

The effects of serotonergic drugs on rodent and human appetite expression will be examined along with the effects of some of these drugs on body weight.

The involvement of 5-HT-like receptors in the regulation of food intake in rainbow trout (Oncorhynchus mykiss).

Serotonin controlling feeding and satiety




The 5-HT1B receptor agonist CP-94,253 reduces food intake and preserves the behavioural satiety sequence

Similarities in the action of Ro 60-0175, a 5-HT2C receptor agonist, and d-fenfluramine on feeding patterns in the rat

The hypothesis that activation of 5-HT2C receptors is a critical aspect of the hypophagic action of d-fenfluramine is supported and may prove to be a useful target in the development of clinically effective drugs for the treatment of obesity.

Infusion of the serotonin1B (5-HT1B) agonist CP-93,129 into the parabrachial nucleus potently and selectively reduces food intake in rats

The results implicate parabrachial 5-HT1B receptors in mediating serotonergic enhancement of satiation and implicate the PBN of the pons in this agonist-induced reduction in food consumption by rats.

Evidence that d-fenfluramine anorexia is mediated by 5-HT1 receptors

The pattern of results obtained strongly suggest that central 5-HT1 receptors play an important role in the mediation of d-fenfluramine-induced anorexia.

Effects of serotonin1/2 receptor agonists on dark-phase food and water intake in rats

CP-94,253: a selective serotonin1B (5-HT1B) agonist that promotes satiety

The results imply that CP-94,253 probes a role for central 5- HT1B receptors in the regulation of meal size and duration, but that recruitment of other 5-HT receptor subtypes may be needed for the full expression of satiety.

Serotonergic control of the organization of feeding and satiety

  • K. Simansky
  • Biology, Psychology
    Behavioural Brain Research
  • 1995

5-HT receptor ligands differentially affect operant oral self-administration of ethanol in the rat.