5-HT1B receptors, ventral orbitofrontal cortex, and aggressive behavior in mice

@article{Almeida20065HT1BRV,
  title={5-HT1B receptors, ventral orbitofrontal cortex, and aggressive behavior in mice},
  author={R. D. Almeida and M. M. Rosa and D. Santos and D. M. Saft and Q. Benini and K. Miczek},
  journal={Psychopharmacology},
  year={2006},
  volume={185},
  pages={441-450}
}
RationaleSystemic injections of 5-HT1B receptor agonists have been shown to have specific anti-aggressive effects in aggressive individuals. One site of action for these drugs is the 5-HT1B receptors in the ventral orbitofrontal cortex (VO PFC), an area that has been implicated in the inhibitory control of behavior and is a terminal region for 5-HT projections.ObjectiveTo assess the anti-aggressive effects of the 5-HT1B receptor agonist CP-94,253 when microinjected into the VO PFC (0.1, 0.56… Expand
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