5-HT1B receptors, ventral orbitofrontal cortex, and aggressive behavior in mice

  title={5-HT1B receptors, ventral orbitofrontal cortex, and aggressive behavior in mice},
  author={Rosa Maria Martins de Almeida and Michelle Melgarejo da Rosa and Daniela M. Santos and D. M. Saft and Quelin Benini and Klaus A. Miczek},
RationaleSystemic injections of 5-HT1B receptor agonists have been shown to have specific anti-aggressive effects in aggressive individuals. One site of action for these drugs is the 5-HT1B receptors in the ventral orbitofrontal cortex (VO PFC), an area that has been implicated in the inhibitory control of behavior and is a terminal region for 5-HT projections.ObjectiveTo assess the anti-aggressive effects of the 5-HT1B receptor agonist CP-94,253 when microinjected into the VO PFC (0.1, 0.56… 

Effect of 5-HT1B receptor agonists injected into the prefrontal cortex on maternal aggression in rats.

It is concluded that only the 5-HT1B receptor agonist CP-93,129 administered into the VO PFC decreased aggression in female rats postpartum after social instigation.

Social instigation and aggressive behavior in mice: role of 5-HT1A and 5-HT1B receptors in the prefrontal cortex

The hypothesis that activation of these receptors modulates high levels of aggression in a behaviorally specific manner is supports the decrease in aggressiveness observed with microinjections of 5- HT1A and 5-HT1B receptor agonists into the VO PFC of socially provoked mice.

Anti-aggressive effects of agonists at 5-HT1B receptors in the dorsal raphe nucleus of mice

These data extend the anti-aggressive effects of 5- HT1B agonists to a type of escalated aggression that is rewarding and further suggest that these effects are associated with actions at 5-HT1B receptors in the dorsal raphe.

Behavioral and pharmacogenetics of aggressive behavior.

There are receptor populations in specific brain regions that preferentially modulate specific types of aggression and specific receptor subpopulations for GABA, glutamate and neuropeptides as they modulate the canonical aminergic neurotransmitters in brainstem, limbic and cortical regions with the ultimate outcome of attenuating or escalating aggressive behavior.

Social instigation and aggression in postpartum female rats: role of 5-Ht1A and 5-Ht1B receptors in the dorsal raphé nucleus and prefrontal cortex

The decrease in maternal aggressive behavior after microinjections of 5-HT1B receptor agonists into the VO PFC and DRN of female postpartum rats that were instigated socially supports the hypothesis that activation of these receptors modulates high levels of aggression in a behaviorally specific manner.

Brain serotonin receptors and transporters: initiation vs. termination of escalated aggression

Tonic increase of the 5-HT2 family expression may cause escalated aggression, whereas the phasic increase of 5- HT2 receptors inhibits aggressive behaviors, and feedback to autoreceptors of the5-HT1 family and modulation via heteroreceptor are important in the expression of aggressive behavior.

Escalated Aggression after Alcohol Drinking in Male Mice: Dorsal Raphé and Prefrontal Cortex Serotonin and 5-HT1B Receptors

It is suggested that 5-HT1B receptors in the mPFC may serve to selectively disinhibit aggressive behavior in mice with a history of Alc self-administration.

5-HT1B receptor inhibition of alcohol-heightened aggression in mice: comparison to drinking and running

These results confirm the inhibitory effects of 5-HT1B receptor stimulation on aggressive performance and drinking and reveal an inhibition of voluntary wheel running, contrary to the stimulation of running in a novel, open arena.

The rewarding effect of aggression is reduced by nucleus accumbens dopamine receptor antagonism in mice

These results suggest that both D1- and D2-like receptors in the ventral striatum are involved in the rewarding properties of aggression, but that D1 -like receptors may be related to the motivation to earn reinforcement as opposed to aggressive behavior.



Alcohol-heightened aggression in mice: attenuation by 5-HT1A receptor agonists

The hypothesized significant role of 5-HT1A receptors in the aggression-heightening effects of alcohol is supported, with results suggesting behavioral specificity of these anti-aggressive effects.

Activation of 5-HT1B receptors in the nucleus accumbens reduces self-administration of amphetamine on a progressive ratio schedule

5-HT1A and 5-HT1B receptor agonists and aggression: a pharmacological challenge of the serotonin deficiency hypothesis.

Zolmitriptan – a 5-HT1B/D agonist, alcohol, and aggression in mice

Zolmitriptan proved to be an effective and behaviorally specific anti-aggressive agent in situations that engender moderate and alcohol-heightened levels of aggression.

Role of 5-HT1B, 5-HT2A and 5-HT2C receptors in the generalization of 5-HT receptor agonists to the ethanol cue in the rat.

The present findings indicate that activation of 5-HT1B and 5- HT2C, but not of5-HT2A receptors, mimics the EtOH cue, and suggests that these receptors play only a minor role in the discriminative stimulus effects of a moderately low dose of EtOH.

5-Hydroxytryptamine1B receptors modulate the effect of cocaine on c-fos expression: converging evidence using 5-hydroxytryptamine1B knockout mice and the 5-hydroxytryptamine1B/1D antagonist GR127935.

Serotonergic transmission has been suggested to modulate the effects of cocaine. However, the specific receptors and brain structures underlying this phenomenon have not been identified. To test the

8-OH-DPAT in the median raphe, dorsal periaqueductal gray and corticomedial amygdala nucleus decreases, but in the medial septal area it can increase maternal aggressive behavior in rats

It is concluded that the main role of the 5-HT1A somatodendritic autoreceptors and the postsynaptic receptors of the brain areas studied is to decrease maternal aggression, however, at a specific dosage, 8-OH-DPAT acting on post synapses of the medial septal area can increase aggressiveness.

Enhanced aggressive behavior in mice lacking 5-HT1B receptor.

The neuromodulator serotonin (5-hydroxytryptamine, 5-HT) has been associated with mood disorders such as depression, anxiety, and impulsive violence. To define the contribution of 5-HT receptor