5-HT1B receptor knockout mice show a compensatory reduction in 5-HT2C receptor function.

@article{Clifton20035HT1BRK,
  title={5-HT1B receptor knockout mice show a compensatory reduction in 5-HT2C receptor function.},
  author={Peter G. Clifton and Michelle Dongeun Lee and Elizabeth M. Somerville and Guy A. Kennett and Colin Trevor Dourish},
  journal={The European journal of neuroscience},
  year={2003},
  volume={17 1},
  pages={185-90}
}
Although null mutant ('knockout') mice have provided valuable animal models to complement traditional approaches to psychopharmacology, such animals may also show complex adaptations to the induced mutation. Here we demonstrate that serotonin1B (5-HT1B) receptor knockout (KO) mice show adaptations in serotonin2C (5-HT2C) receptor-mediated functions. They show smaller reductions in food intake and locomotor activity in response to administration of 5-HT2C receptor agonists that are not accounted… CONTINUE READING
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