5-HT1B Receptor–Mediated Presynaptic Inhibition of Retinal Input to the Suprachiasmatic Nucleus

  title={5-HT1B Receptor–Mediated Presynaptic Inhibition of Retinal Input to the Suprachiasmatic Nucleus},
  author={G. E. Pickard and B. Smith and M. Belenky and M. Rea and F. E. Dudek and P. J. Sollars},
  journal={The Journal of Neuroscience},
  pages={4034 - 4045}
  • G. E. Pickard, B. Smith, +3 authors P. J. Sollars
  • Published 1999
  • Biology, Medicine
  • The Journal of Neuroscience
  • The suprachiasmatic nucleus (SCN) receives glutamatergic afferents from the retina and serotonergic afferents from the midbrain, and serotonin (5-HT) can modify the response of the SCN circadian oscillator to light. 5-HT1B receptor-mediated presynaptic inhibition has been proposed as one mechanism by which 5-HT modifies retinal input to the SCN (Pickard et al., 1996). This hypothesis was tested by examining the subcellular localization of 5-HT1Breceptors in the mouse SCN using electron… CONTINUE READING
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