5-HT1A-receptor over-expressing mice: Genotype and sex dependent responses to antidepressants in the forced swim-test

@article{Gnther20115HT1AreceptorOM,
  title={5-HT1A-receptor over-expressing mice: Genotype and sex dependent responses to antidepressants in the forced swim-test},
  author={Lydia G{\"u}nther and Julia Rothe and Andr{\'e} Rex and J Voigt and Mark John Millan and Heidrun Fink and Bettina Bert},
  journal={Neuropharmacology},
  year={2011},
  volume={61},
  pages={433-441}
}
Deficiencies in serotonergic neurotransmission are involved in the pathophysiology of depression. Due to its modulatory effect on serotonin (5-HT) release, the 5-HT(1A)-receptor is thought to play a decisive role in the therapy of this mood disorder. However, it is not fully understood how antidepressant effects are mediated by pre- and postsynaptic receptor sites. In this study we examined the impact of postsynaptic 5-HT(1A)-receptor over-expression in corticolimbic areas of male and female… CONTINUE READING

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Dissociating the Roles of the 5-HT1A Auto- and Heteroreceptors in Depression and Anxiety: Insights from a Novel Genetic Mouse System

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