5-HT1A receptor antagonists and lordosis behavior.

  title={5-HT1A receptor antagonists and lordosis behavior.},
  author={Lynda L. Uphouse and Maydianne C B Andrade and M Caldarola-Pastuszka and Astra Jackson},
  volume={35 4},
In proestrous rats, serotonin 1A (5-HT1A) receptor agonists inhibit lordosis behavior within 5-15 min following infusion into the ventromedial nucleus of the hypothalamus (VMN). In the present report, the lordosis-inhibiting effects of the 5-HT1A agonist [(+/-) 8-hydroxy-2- (di-n-propylamino) tetralin) (8-OH-DPAT] were shown to be attenuated with 5-HT1A receptor antagonists. Two compounds, propranolol and pindolol, that function as both beta-adrenergic and 5-HT1A receptor antagonists, and… CONTINUE READING


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