5-HT1A receptor agonists prevent in rats the yawning and penile erections induced by direct dopamine agonists

  title={5-HT1A receptor agonists prevent in rats the yawning and penile erections induced by direct dopamine agonists},
  author={Philippe Simon and B{\'e}atrice Guardiola and Jean-Guy Bizot-Espiard and Pierre Schiavi and Jean Costentin},
The new compound (+) S-20499, an amino chromane derivative (8[-4[N-(5-methoxychromane-3yl)N-propyl]aminobutyl] azaspiro[4–5] décane-7,9 dione), is a high affinity full 5-HT1A agonist. We have investigated its effects on dopaminergic transmission. (+) S-20499 displayed a 10−8 M affinity for D2 dopamine (DA) receptors, 100 fold lower than for 5-HT1A receptors. The hypothermic effect of the drug was reversed by haloperidol in mice, suggesting that it behaves as a direct dopamine agonist. However… 

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