5-HT1A receptor agonist-mediated protection from MPTP toxicity in mouse and macaque models of Parkinson's disease

@article{Bzard20065HT1ARA,
  title={5-HT1A receptor agonist-mediated protection from MPTP toxicity in mouse and macaque models of Parkinson's disease},
  author={Erwan B{\'e}zard and Irene Gerlach and Rosario Moratalla and Christian Gross and Reinhard Jork},
  journal={Neurobiology of Disease},
  year={2006},
  volume={23},
  pages={77-86}
}
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63 Citations
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63 Citations

Rotigotine treatment partially protects from MPTP toxicity in a progressive macaque model of Parkinson's disease

Combined 5-HT1A and 5-HT1B receptor agonists for the treatment of L-DOPA-induced dyskinesia.

The results demonstrate the existence of a potent synergistic effect between 5- HT(1A) and 5-HT(1B) agonists in their ability to dampen l-DOPA-induced dyskinesia in the MPTP-treated macaques.

Dopamine Transporter Binding Is Unaffected by L-DOPA Administration in Normal and MPTP-Treated Monkeys

Data indicate that L-DOPA does not induce modifications of DAT expression detectable by SPECT of by DAT binding autoradiography, suggesting that differences between clinical assessment and radiotracer imaging in clinical trials may not be specifically related to L- DOPA treatment.

Targeting 5-HT1A receptors in astrocytes to protect dopaminergic neurons in parkinsonian models

Different Alterations of Agonist and Antagonist Binding to 5-HT1A Receptor in a Rat Model of Parkinson's Disease and Levodopa-Induced Dyskinesia: A microPET Study.

The data suggest that agonist and antagonist 5-HT1A receptor-binding sites are differently modified in Parkinson's disease and levodopa-induced dyskinesia and emphasize the need to characterize this state using agonist radiotracers in physiological and pathological conditions.

Effects of coincident 5-HT1A receptor stimulation and NMDA receptor antagonism on l-DOPA-induced dyskinesia and rotational behaviors in the hemi-parkinsonian rat

Combined subthreshold doses of ±8-OH-DPAT and MK-801 dose-dependently decreased l-DOPA-induced AIMs without affecting rotations and indicate a functional interaction between 5-HT1AR and NMDAR that may improve pharmacological treatment of PD patients.

Serotonin 1A Receptors on Astrocytes as a Potential Target for the Treatment of Parkinson’s Disease

The neuroprotective properties of astrocytes targeting certain molecules related to PD are summarized and new promising therapeutic strategies based on neuroprotection against oxidative stress and prevention of dopaminergic neurodegeneration are discussed.

Animal models of Parkinson's disease: a source of novel treatments and clues to the cause of the disease

The MPTP‐treated primate model of PD, which closely mimics the clinical features of PD and in which all currently used anti‐parkinsonian medications have been shown to be effective, is undoubtedly the most clinically‐relevant of all available models.

The differential effects of 5-HT1A receptor stimulation on dopamine receptor-mediated abnormal involuntary movements and rotations in the primed hemiparkinsonian rat

New insight into the therapeutic role of the serotonergic system in Parkinson's disease

...

References

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