5-HT1A receptor agonist-mediated protection from MPTP toxicity in mouse and macaque models of Parkinson's disease

@article{Bzard20065HT1ARA,
  title={5-HT1A receptor agonist-mediated protection from MPTP toxicity in mouse and macaque models of Parkinson's disease},
  author={Erwan B{\'e}zard and Irene Gerlach and Rosario Moratalla and Christian Gross and Reinhard Jork},
  journal={Neurobiology of Disease},
  year={2006},
  volume={23},
  pages={77-86}
}
Excitotoxicity-mediated cell death is involved in Parkinson's disease (PD). 5-HT1A receptor agonists can protect from such mechanisms. The current study demonstrates that the 5-HT1A agonists BAY 639044 and repinotan have neuroprotective effects in a subacute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of PD. In addition, we also show that both compounds delay the appearance of parkinsonian motor abnormalities in a MPTP monkey model that recapitulates the progressive nature… 
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TLDR
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TLDR
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TLDR
The present findings indicate that 5-HT(1A)R stimulation reduces AIMs induced by D1R, D2R and l-DOPA administration while its effects on DA agonist-induced rotations were receptor-dependent, suggesting that direct 5- HT(1 a)R and DA receptor interactions may contribute to the unique profile of 5-ht(1a)R agonists for the improvement of PD treatment.
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