5-HT1A and beyond: the role of serotonin and its receptors in depression and the antidepressant response.

@article{Cryan20005HT1AAB,
  title={5-HT1A and beyond: the role of serotonin and its receptors in depression and the antidepressant response.},
  author={John F Cryan and Brian E. Leonard},
  journal={Human psychopharmacology},
  year={2000},
  volume={15 2},
  pages={113-135}
}
Since its discovery 50 years ago, the role of the indoleamine 5-HT (5-hydroxytryptamine; serotonin) in the pathogenesis of depression and in the mechanism of action of antidepressant drugs has been the subject of considerable research. Advances in molecular biology and radioligand techniques have led to the functional characterisation of at least 14 serotonin receptor subtypes. This classification has led to the development of selective compounds that have aided in the efforts of dissecting the… CONTINUE READING