5-HT1A agonists disrupt memory of fear conditioning in mice

@article{Quartermain19935HT1AAD,
  title={5-HT1A agonists disrupt memory of fear conditioning in mice},
  author={D. Quartermain and Jonathan Clemente and A. Shemer},
  journal={Biological Psychiatry},
  year={1993},
  volume={33},
  pages={247-254}
}
A series of experiments was carried out to analyze the effects of the 5-HT1A agonists tandospirone or buspirone on the retention of fear conditioning in mice. Fear was produced by pairing tone and shock in a conditioned emotional response (CER) paradigm and strength of conditioning was assessed by measuring suppression of drinking in presence of tone. Fear conditioning was disrupted if tandospirone and buspirone were administered before the conditioning session but not before the test trial… Expand
Reinstatement of conditioned suppression in mice
Return of fear after successful exposure therapy calls for a better understanding of the mechanisms of relapse. Classical conditioning research provides a useful framework for conceptualising theExpand
The 5-HT1A agonist tandospirone disrupts retention but not acquisition of active avoidance learning
TLDR
Findings confirm previous suggestions that 5-HT1A agonists can cause anterograde amnesia, and show that retention was significantly disrupted by the 1- and 5-mg/kg doses. Expand
Pre‐ or post‐training injection of buspirone impaired retention in the inhibitory avoidance task: involvement of amygdala 5‐HT1A receptors
  • K. Liang
  • Psychology, Medicine
  • The European journal of neuroscience
  • 1999
TLDR
The findings suggest that buspirone may modulate memory storage processes in the inhibitory avoidance task through an action on amygdaloid 5‐HT1A receptors. Expand
Vortioxetine dose-dependently reverses 5-HT depletion-induced deficits in spatial working and object recognition memory: A potential role for 5-HT1A receptor agonism and 5-HT3 receptor antagonism
TLDR
Vortioxetine's effects on SA performance may involve 5-HT1A receptor agonism, but not5-HT3 receptor antagonism, whereas the effects on OR performance may involved 5- HT3 receptor antagonists and 5-ht1Aceptor agonism. Expand
Behavioral effects of buspirone in a mouse model of posttraumatic stress disorder
TLDR
Positive effects of buspirone are suggested in the treatment of selected PTSD-like symptoms and prompt for its further clinical evaluation. Expand
Attenuation of fear-like response by escitalopram treatment after electrical stimulation of the midbrain dorsolateral periaqueductal gray
TLDR
The results suggest that the fear-like response, which was observed 12 h after dlPAG stimulation, could be considered as a relevant animal model for panic disorder with anticipatory anxiety/agoraphobic symptoms. Expand
Dual role of serotonin in the acquisition and extinction of reward-driven learning: Involvement of 5-HT1A, 5-HT2A and 5-HT3 receptors
TLDR
Data showed a differential role of 5-HT in the acquisition and extinction of an operant conditioning task, suggesting that it may have a dual function in reward encoding. Expand
Pharmacological Enhancement of Memory and Executive Functioning in Laboratory Animals
TLDR
Viewed collectively, studies of the neuropharmacological basis of cognition in rodents and non-human primates have identified targets that will hopefully open new avenues for the treatment of cognitive disabilities in persons affected by mental disorders. Expand
The role of the serotonin receptor subtypes 5-HT1A and 5-HT7 and its interaction in emotional learning and memory
TLDR
Findings highlight the differential role of these 5-HTRs in cognitive/emotional domains of behavior and indicate that tonic and phasic 5-HT release can exert different and potentially opposing effects on emotional memory, depending on the states of5-HT1ARs and 5- HT7Rs and their interaction. Expand
Measurement of Anxiety in Transgenic Mice
TLDR
The most commonly used models of anxiety suitable for screening transgenic and knockout mice are discussed, with an emphasis placed on controlling for factors which could confound results. Expand
...
1
2
...

References

SHOWING 1-10 OF 18 REFERENCES
Attenuation of forgetting by pharmacological stimulation of aminergic neurotransmitter systems
TLDR
It was concluded that pharmacological agents which stimulate monoamine systems may improve memory retrieval by activating a non-specific neural system which controls arousal, attention and motor readiness. Expand
N-methyl-D-aspartate receptor antagonist APV blocks acquisition but not expression of fear conditioning.
TLDR
Effects on fear conditioning are parallel to the in vitro effects of APV on the acquisition but not expression of long-term potentiation (LTP) and suggest that endogenously generated NMDA-dependent LTP participates in the neural plasticity underlying fear conditioning. Expand
Amphetamine enhances retrieval following diverse sources of forgetting
TLDR
It is concluded that amphetamine can alleviate forgetting caused by widely diverse etiologies probably by activating a nonspecific general retrieval system. Expand
Alleviation of scopolamine amnesia by different retrieval enhancing treatments
TLDR
The data show that scopolamine amnesia can be alleviated by treatments which activate retrieval processes and improved by exposure to the CS and the UCS. Expand
Effect of Chlordiazepoxide Administered Early in Extinction on Subsequent Extinction of a Conditioned Emotional Response in Rats: Implications for Human Clinical Use
  • M. Goldman
  • Psychology, Medicine
  • Psychological reports
  • 1977
TLDR
The results suggest caution in the use of chlordiazepoxide in human clinical situations when the fear stimuli are delineated and the hope is for anxiety reduction that continues after withdrawal of the drug. Expand
Differential effects of the anxiolytic drugs, diazepam and buspirone, on memory function.
The effects of the anxiolytic drugs diazepam (5 mg) or buspirone (5 or 10 mg) were studied in comparison with placebo on memory function in 39 subjects diagnosed with generalized anxiety disorder.Expand
The neurochemistry and pharmacology of extinction behavior
  • S. Mason
  • Medicine, Psychology
  • Neuroscience & Biobehavioral Reviews
  • 1983
TLDR
It is suggested that the noradrenergic system may be involved in the expression of extinction behavior by a role in selective attention, the dopamine system via an involvement with secondary reinforcement, the cholinergic system by a mechanism of response inhibition and the barbiturates and benzodiazepines by a block of nonreward. Expand
Electrophysiological responses of serotoninergic dorsal raphe neurons to 5‐HT1A and 5‐HT1B agonists
TLDR
D dorsal raphe 5‐HT neurons appear highly responsive to 5‐ht1A, but not to 5-HT1B compounds; these findings are discussed with regard to the 5‐ HT receptor subtypes as candidates for the somatodendritic autoreceptor of dorsal raphes neurons. Expand
What is the nature of the role of the serotonergic nervous system in learning and memory: Prospects for development of an effective treatment strategy for senile dementia
TLDR
The results of a number of studies designed to gain further insight into the role the serotonergic nervous system plays in learning and memory clearly belie a selective role of this neurotransmitter in the processes underlyingLearning and memory and further underscore the complex nature of this system's role in the processing of information by the brain. Expand
Buspirone and diazepam: comparison of subjective, psychomotor and biological effects.
The effects of oral buspirone (BUS, 10 mg) and diazepam (DZP, 10 mg) were studied in 12 healthy women volunteers using subjective ratings, objective tests of psychomotor and cognitive functions andExpand
...
1
2
...