5-HT stimulation of heart rate in Drosophila does not act through cAMP as revealed by pharmacogenetics.

@article{Majeed20135HTSO,
  title={5-HT stimulation of heart rate in Drosophila does not act through cAMP as revealed by pharmacogenetics.},
  author={Zana R. Majeed and Charles D Nichols and Robin L Cooper},
  journal={Journal of applied physiology},
  year={2013},
  volume={115 11},
  pages={1656-65}
}
The fruit fly, Drosophila melanogaster, is a good experimental organism to study the underlying mechanism of heart rate (HR) regulation. It is already known that many neuromodulators (serotonin, dopamine, octopamine, acetylcholine) change the HR in Drosophila melanogaster larvae. In this study, we investigated the role of cAMP-PKA signaling pathway in HR regulation and 5-HT positive chronotropic action. In order to obtain insight into the 5-HT mechanism of action in larvae cardiomyocytes… CONTINUE READING
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