5-HT inhibits synaptic transmission in rat subthalamic nucleus neurons in vitro.


The subthalamic nucleus (STN) plays a pivotal role in normal and abnormal motor function. We used patch pipettes to study effects of 5-HT on synaptic currents evoked in STN neurons by focal electrical stimulation of rat brain slices. 5-HT (10 microM) reduced glutamate-mediated excitatory postsynaptic currents (EPSCs) by 35+/-4%. However, a much higher… (More)
DOI: 10.1016/j.neuroscience.2007.12.001


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