5-HT in systemic hypertension: foe, friend or fantasy?

@article{Watts20055HTIS,
  title={5-HT in systemic hypertension: foe, friend or fantasy?},
  author={Stephanie W Watts},
  journal={Clinical science},
  year={2005},
  volume={108 5},
  pages={
          399-412
        }
}
Since its discovery by Erspamer in the 1930s and identification by Page in the 1950s, 5-HT (5-hydroxytryptamine; serotonin) has been an elusive candidate as a substance that plays a role in the disease of high blood pressure, also known as hypertension. In both animal and human hypertension, arterial contraction to 5-HT is profoundly enhanced. Additionally, 5-HT is a vascular smooth muscle cell mitogen. Because both increased arterial contractility and smooth muscle growth contribute to the… CONTINUE READING
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