5-HT control of ischemia-evoked glutamate efflux from human cerebrocortical slices.

@article{Marcoli20045HTCO,
  title={5-HT control of ischemia-evoked glutamate efflux from human cerebrocortical slices.},
  author={Manuela Marcoli and Chiara Cervetto and M Castagnetta and Pierfilippo Sbaffi and Guido Maura},
  journal={Neurochemistry international},
  year={2004},
  volume={45 5},
  pages={687-91}
}
The aim of the present investigation was to explore if glutamate efflux from human cerebrocortical slices caused by oxygen/glucose deprivation can be controlled by 5-hydroxytryptamine (5-HT). Slices were superfused in aerobic conditions or in conditions simulating moderate ischemic insult (24 min oxygen and glucose deprivation) and the efflux of previously accumulated [3H]D-aspartate and of endogenous glutamate was measured in superfusate fractions. The efflux of both [3H]D-aspartate and… CONTINUE READING