5-HT antagonists NAN-190 and SB 269970 block &agr;2-adrenoceptors in the guinea pig

  title={5-HT antagonists NAN-190 and SB 269970 block &agr;2-adrenoceptors in the guinea pig},
  author={J. P. P. Foong and J. Bornstein},
  • J. P. P. Foong, J. Bornstein
  • Published 2009
  • Biology, Medicine
  • NeuroReport
  • Serotonin (5-HT) plays a significant role in the regulation of intestinal secretion of water and electrolytes. The initial aim of this study was to use intracellular recording and specific antagonists to identify roles of 5-HT1A and 5-HT7 receptors of submucosal noncholinergic secretomotor neurons of guinea pig ileum, in vitro. However, it was found that the widely used 5-HT receptor antagonists NAN-190 (5-HT1A) and SB 269970 (5-HT7) both blocked &agr;2-adrenoceptors, and hence depressed… CONTINUE READING
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