5-HT acts on nociceptive primary afferents through an indirect mechanism to induce hyperalgesia in the subcutaneous tissue.

@article{Oliveira20075HTAO,
  title={5-HT acts on nociceptive primary afferents through an indirect mechanism to induce hyperalgesia in the subcutaneous tissue.},
  author={Maria Cl{\'a}udia Gonçalves Oliveira and Adriana Pelegrini-da-Silva and Carlos Am{\'i}lcar Parada and Cl{\'a}udia Herrera Tambeli},
  journal={Neuroscience},
  year={2007},
  volume={145 2},
  pages={708-14}
}
We have recently demonstrated that s.c.-injected 5-hydroxytryptamine (5-HT) induces nociception by an indirect action on the primary afferent nociceptor in addition to its previously described direct action. Although the mechanisms mediating hyperalgesia can be quite separate and distinct from those mediating nociception, the aim of this study was to test the hypothesis that 5-HT induces mechanical hyperalgesia by mechanisms similar to those mediating nociception. s.c. injection of 5-HT induced… CONTINUE READING