5-HT(2) receptor-mediated phosphoinositide hydrolysis in bovine ciliary epithelium.

  title={5-HT(2) receptor-mediated phosphoinositide hydrolysis in bovine ciliary epithelium.},
  author={Eri Inoue-Matsuhisa and Sayoko E. Moroi and Hisashi Takenaka and Shunji Sogo and Tomiya Mano},
  journal={Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics},
  volume={19 1},
The serotonin 2 (5-HT(2)) receptor antagonists, MCI-9042 (Anplag) and ketanserin, have been shown to lower intraocular pressure in rabbits (1) and humans (2). The mechanism of action of these drugs has not been determined, but it is hypothesized that 5-HT(2) receptors, and possibly alpha-adrenergic receptors, (3) may regulate in part aqueous humor production via an intracellular signal transduction pathway in the ciliary body. We therefore examined whether 5-HT(2) receptors were coupled to… CONTINUE READING
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