5-HMF prevents against oxidative injury via APE/Ref-1.

  title={5-HMF prevents against oxidative injury via APE/Ref-1.},
  author={J Zhang and Ye Di and L-y Wu and Y. N. He and Tian-Cheng Zhao and Xinzhi Huang and X-F Ding and K. Wu and M Fan and L-l Zhu},
  journal={Free radical research},
  volume={49 1},
Oxidative injury is involved in many diseases, including ischemic and neurodegenerative diseases. Antioxidant drugs can be used to relieve the oxidative injury caused by these diseases; however, there are very few antioxidant drugs available for clinical use. In this study, we found that 5-(hydroxymethyl)-2-furfural (5-HMF) protects against the oxidative damage induced by cerebral ischemia in rats or by hydrogen peroxide (H2O2) in PC12 cells. We demonstrated that 5-HMF performs this function… CONTINUE READING


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