5-Fluorouracil up-regulates interferon pathway gene expression in esophageal cancer cells.

@article{Matsumura20055FluorouracilUI,
  title={5-Fluorouracil up-regulates interferon pathway gene expression in esophageal cancer cells.},
  author={Yumiko Matsumura and Masakazu Yashiro and Masaichi Ohira and Hisahiro Tabuchi and Kosei Hirakawa},
  journal={Anticancer research},
  year={2005},
  volume={25 5},
  pages={3271-8}
}
5-Fluorouracil (FU) is a chemotherapeutic agent commonly used against esophageal cancer. Recently, interferons (IFNs) have been administered together with cytotoxic chemotherapy to patients with this cancer, although the mechanisms of synergy are unknown. We reconsidered the mechanisms for the effects of 5-FU in this context, aiming to refine combination… CONTINUE READING