5-Fluorouracil is efficiently removed from DNA by the base excision and mismatch repair systems.

@article{Fischer20075FluorouracilIE,
  title={5-Fluorouracil is efficiently removed from DNA by the base excision and mismatch repair systems.},
  author={Franziska Fischer and Katja Baerenfaller and Josef Jiricny},
  journal={Gastroenterology},
  year={2007},
  volume={133 6},
  pages={1858-68}
}
BACKGROUND & AIMS 5-Fluorouracil (FU) is one of the mainstays of colon cancer chemotherapy. Although developed as an inhibitor of thymidylate synthase, its cytotoxicity has been linked also to its incorporation into RNA. Surprisingly, although FU is incorporated also into DNA, little is known about its metabolism in this nucleic acid. METHODS Using extracts of human cells and circular DNA substrates containing a single FU residue either paired with adenine or mispaired with guanine, we… CONTINUE READING
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